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All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase...
Editeur :
Wiley
Parution :
2010-01-19
PDF
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Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated...
Editeur :
Wiley
Parution :
2010-01-06
Collection :
Wiley Series in Drug Discovery and Development
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PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is...
Editeur :
Wiley
Parution :
2010-01-05
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"The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to...
Editeur :
Wiley-Blackwell
Parution :
2009-12-17
ePub
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The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of...
Editeur :
Wiley
Parution :
2009-12-09
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Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one...
Editeur :
Wiley
Parution :
2009-11-19
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
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By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges...
Editeur :
Wiley-VCH
Parution :
2009-11-18
PDF
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Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and...
Editeur :
Wiley
Parution :
2009-10-22
Collection :
Wiley Series in Drug Discovery and Development
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A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical...
Editeur :
Wiley
Parution :
2009-10-22
PDF
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Drug Bioavailability In order to reach its intended site of action, the drug molecules in every pill that we swallow must first be absorbed, transported via the bloodstream and evade various mechanisms that eliminate drugs from the body. Those drug properties that...
Editeur :
Wiley-VCH
Parution :
2009-09-18
Collection :
Methods & Principles in Medicinal Chemistry
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results.The Novartis...
Editeur :
Wiley
Parution :
2009-09-16
Collection :
Novartis Foundation Symposia
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results.The Novartis...
Editeur :
Wiley
Parution :
2009-09-16
Collection :
Novartis Foundation Symposia
PDF
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results.The Novartis...
Editeur :
Wiley
Parution :
2009-09-16
Collection :
Novartis Foundation Symposia
PDF
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A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the...
Editeur :
Wiley
Parution :
2009-09-01
PDF
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Chronopharmaceutics Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases Edited by Bi-Botti C. Youan The first standard reference on chronopharmaceutics As we better understand how biological processes unfold in real time through...
Editeur :
Wiley
Parution :
2009-08-26
PDF
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Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and...
Editeur :
Wiley
Parution :
2009-08-06
PDF
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Benefit-risk assessment is at the centre of the approval process for every new medicine. The ability to assess the risks of a new medicine accurately and to balance these against the benefits the medicine could bring is critical for every regulatory authority and...
Editeur :
Wiley
Parution :
2009-08-04
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Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore...
Editeur :
Wiley-VCH
Parution :
2009-07-10
Collection :
Methods & Principles in Medicinal Chemistry
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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability...
Editeur :
Wiley
Parution :
2009-06-17
Collection :
Wiley Series in Drug Discovery and Development
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This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for...
Editeur :
Wiley
Parution :
2009-04-06
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